Monamine oxidase and head-twitch response in mice mechanisms of α-methylated substrate derivatives

被引：14

作者：

Nakagawasai, O ^{[1
]}

Arai, Y

Satoh, S

Satoh, N

Neda, M

Hozumi, M

Oka, R

Hiraga, H

Tadano, T

机构：

[1] Tohoku Pharmaceut Univ, Dept Pharmacol, Sendai, Miyagi 9818558, Japan

[2] Showa Univ, Sch Med, Dept Pharmacol, Tokyo 1428555, Japan

[3] Chiba Univ, Grad Sch Pharmaceut Sci, Dept Drug Informat & Commun, Chiba 2638522, Japan

来源：

NEUROTOXICOLOGY | 2004年 / 25卷 / 1-2期

关键词：

monoamine oxidase; neurotransmitters; mice;

D O I：

10.1016/S0161-813X(03)00101-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

It is well known that head-twitch response (HTR) in mice represents hallucinations, since administration of lysergic acid diethylamide (LSD) produces hallucinations in humans, and the HTR in mice is induced by administration of LSD as a hallucinogen. The HTR is produced by excitation of 5-hydroxytryptamine (5-HT)(2A) receptors. In this paper, we review the mechanisms of HTR induced by various drugs such as 5-HT precursor, 5-HT receptor agonist, 5-HT releaser, hallucinogenic compounds, benzodiazepins and cannabinoid. The response induced by HTR-inducers is significantly enhanced by combined treatment with a non-selective form of monoamine oxidase (MAO) inhibitor Thus, the relationship between MAO activity and HTR caused by these drugs (especially, a-methylated analogous compounds which 5-fluoro-alpha-methyltryptamine, 6-fluoro-alpha-methyltryptamine and p-hydroxyamphetamine) is presented in detail. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：223 / 232

页数：10

共 75 条

[1]

Abell CW, 2001, PROG NUCLEIC ACID RE, V65, P129

[2]

MONOAMINE-OXIDASE INHIBITORS AND THE CHEESE EFFECT [J].

ANDERSON, MC ;

HASAN, F ;

MCCRODDEN, JM ;

TIPTON, KF .

NEUROCHEMICAL RESEARCH, 1993, 18 (11) :1145-1149

[3]

SELECTIVE-INHIBITION OF MAO-A IN SEROTONERGIC SYNAPTOSOMES BY 2 AMPHETAMINE METABOLITES, PARA-HYDROXYAMPHETAMINE AND PARA-HYDROXYNOREPHEDRINE [J].

ARAI, Y ;

KIM, SK ;

KINEMUCHI, H ;

TADANO, T ;

SATOH, S ;

SATOH, N ;

OYAMA, K ;

KISARA, K .

NEUROCHEMISTRY INTERNATIONAL, 1990, 17 (04) :587-592

[4]

INHIBITION OF BRAIN TYPE-A MONOAMINE-OXIDASE AND 5-HYDROXYTRYPTAMINE UPTAKE BY 2 AMPHETAMINE METABOLITES, PARA-HYDROXYAMPHETAMINE AND PARA-HYDROXYNOREPHEDRINE [J].

ARAI, Y ;

KIM, SK ;

KINEMUCHI, H ;

TADANO, T ;

SATOH, SE ;

SATOH, N ;

KISARA, K .

JOURNAL OF NEUROCHEMISTRY, 1990, 55 (02) :403-408

[5]

STUDIES OF MONOAMINE-OXIDASE AND SEMICARBAZIDE-SENSITIVE AMINE OXIDASE .2. INHIBITION BY ALPHA-METHYLATED SUBSTRATE-ANALOG MONOAMINES, ALPHA-METHYLTRYPTAMINE, ALPHA-METHYLBENZYLAMINE AND 2 ENANTIOMERS OF ALPHA-METHYLBENZYLAMINE [J].

ARAI, Y ;

TOYOSHIMA, Y ;

KINEMUCHI, H .

JAPANESE JOURNAL OF PHARMACOLOGY, 1986, 41 (02) :191-197

[6]

ARAI Y, 1992, BIOGENIC AMINES, V8, P413

[7]

SELECTIVE-INHIBITION OF MONOAMINE-OXIDASE IN MONO-AMINERGIC NEURONS IN THE RAT-BRAIN [J].

ASK, AL ;

FAGERVALL, I ;

ROSS, SB .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1983, 324 (02) :79-87

[8]

Chronic cocaine exposure potentiates prolactin and head shake responses to 5-HT2 receptor stimulation in rats [J].

Baumann, MH ;

Rothman, RB .

NEUROPHARMACOLOGY, 1996, 35 (03) :295-301

[9]

mCPP-induced anxiety in the light-dark box in rats -: a new method for screening anxiolytic activity [J].

Bilkei-Gorzó, A ;

Gyertyán, I ;

Lévay, G .

PSYCHOPHARMACOLOGY, 1998, 136 (03) :291-298

[10]

AGGRESSIVE-BEHAVIOR AND ALTERED AMOUNTS OF BRAIN-SEROTONIN AND NOREPINEPHRINE IN MICE LACKING MAOA [J].

CASES, O ;

SEIF, I ;

GRIMSBY, J ;

GASPAR, P ;

CHEN, K ;

POURNIN, S ;

MULLER, U ;

AGUET, M ;

BABINET, C ;

SHIH, JC ;

DEMAEYER, E .

SCIENCE, 1995, 268 (5218) :1763-1766

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