Syntheses and reactions of optically active α-aminoallenylstannanes

被引：39

作者：

Ranslow, PBD ^{[1
]}

Hegedus, LS ^{[1
]}

Rios, CDL ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 01期

关键词：

D O I：

10.1021/jo0302861

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lithiation/stannylation of optically active N-propargyloxazolidinones produced optically active alpha-oxazolidinonylallenylstannanes. Reaction of these with aldehydes in the presence of BF3.OEt2 produced beta-hydroxypropargylamines with high syn diastereoselectivity and ee. These were converted to gamma-hydroxy-beta-amino acids by oxidative cleavage of the alkyne.

引用

页码：105 / 111

页数：7

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