Growth Control by Committee: Intercellular Junctions, Cell Polarity, and the Cytoskeleton Regulate Hippo Signaling

被引：110

作者：

Boggiano, Julian C. ^{[1
,2
]}

Fehon, Richard G. ^{[1
,2
]}

机构：

[1] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA

[2] Univ Chicago, Comm Dev Regenerat & Stem Cell Biol, Chicago, IL 60637 USA

来源：

DEVELOPMENTAL CELL | 2012年 / 22卷 / 04期

基金：

美国国家卫生研究院;

关键词：

TUMOR-SUPPRESSOR PATHWAY; CONTROLS TISSUE-GROWTH; IMAGINAL DISC GROWTH; PROMOTES APOPTOSIS; YAP ONCOPROTEIN; ORGAN SIZE; YORKIE PHOSPHORYLATION; TRANSCRIPTIONAL OUTPUT; PROLIFERATION ARREST; CONTACT INHIBITION;

D O I：

10.1016/j.devcel.2012.03.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Over the past decade, the Hippo tumor suppressor pathway has emerged as a central regulator of growth in epithelial tissues. Research in Drosophila and in mammals has shown that this kinase signaling cascade regulates the activity of the transcriptional coactivator and oncoprotein Yorkie/Yap. In this review, we discuss recent findings that emphasize the cell cortex-specifically the actin cytoskeleton, intercellular junctions, and protein complexes that determine cell polarity-as a key site for Hippo pathway regulation. We also highlight where additional research is needed to integrate known functional interactions between Hippo pathway components.

引用

页码：695 / 702

页数：8

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