Iron-catalyzed intramolecular O-arylation:: Synthesis of 2-aryl benzoxazoles

被引：178

作者：

Bonnamour, Julien ^{[1
]}

Bolm, Carsten ^{[1
]}

机构：

[1] Univ Aachen, Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 13期

关键词：

D O I：

10.1021/ol800744y

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A practical iron-catalyzed intramolecular O-arylation reaction and its application in the synthesis of benzoxazole derivatives, starting from the readily available 2-haloanilines, is presented. The key cyclization step involves the use of a combination of the cheap and environmentally friendly FeCl3 and 2,2,6,6-tetramethyl-3,5 heptanedione (TMHD) as the catalyst system.

引用

页码：2665 / 2667

页数：3

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