Parallel approach to selective catalysts for palladium-catalyzed desymmetrization of 2,4-cyclopentenediol

被引：34

作者：

Agarkov, A ^{[1
]}

Uffman, EW ^{[1
]}

Gilbertson, SR ^{[1
]}

机构：

[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 12期

关键词：

D O I：

10.1021/ol034548x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Work toward the development of a bis-phosphine ligand system for the palladium-catalyzed desymmetrization of meso-diols is reported. A parallel approach using phosphine-containing amino acids and a "representational search" was taken to find a polymer-supported catalyst system. The selectivities reported are comparable to many other polymer-bound asymmetric catalysts.

引用

页码：2091 / 2094

页数：4

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