Parallel approach to selective catalysts for palladium-catalyzed desymmetrization of 2,4-cyclopentenediol

被引:34
作者
Agarkov, A [1 ]
Uffman, EW [1 ]
Gilbertson, SR [1 ]
机构
[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA
关键词
D O I
10.1021/ol034548x
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Work toward the development of a bis-phosphine ligand system for the palladium-catalyzed desymmetrization of meso-diols is reported. A parallel approach using phosphine-containing amino acids and a "representational search" was taken to find a polymer-supported catalyst system. The selectivities reported are comparable to many other polymer-bound asymmetric catalysts.
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页码:2091 / 2094
页数:4
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