A dynamic machinery for import of mitochondrial precursor proteins

被引：68

作者：

Bohnert, Maria ^{[1
]}

Pfanner, Nikolaus ^{[1
]}

van der Laan, Martin ^{[1
]}

机构：

[1] Univ Freiburg, Inst Biochem & Mol Biol, Zentrum Biochem & Mol Zellforsch, D-79104 Freiburg, Germany

来源：

FEBS LETTERS | 2007年 / 581卷 / 15期

关键词：

mitochondria; protein import; sorting and assembly; translocase of inner membrane complex; presequence translocase-associated motor complex; mitochondrial intermembrane space import and assembly pathway; TRANSLOCATION CONTACT SITES; INTERMEMBRANE SPACE; PRESEQUENCE TRANSLOCASE; PREPROTEIN TRANSLOCASE; OUTER-MEMBRANE; INNER MEMBRANE; ASSEMBLY MACHINERY; TOM40; FORMS; COMPLEX; MOTOR;

D O I：

10.1016/j.febslet.2007.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria contain similar to 1000 different proteins, which are located in four different compartments, outer membrane, inner membrane, intermembrane space and matrix. The vast majority of these proteins has to be imported from the cytosol. Therefore, sophisticated molecular machineries have evolved that mediate protein translocation across or insertion into mitochondrial membranes and subsequent assembly into multi-subunit complexes. While the initial entry of virtually all mitochondrial proteins is mediated by the general import pore of the outer membrane, at least four different downstream pathways are dedicated to import and assembly of proteins into a specific compartment. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：2802 / 2810

页数：9

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