Infrared microscopy characterisation of carotid plaques and thyroid tissue biopsies

被引：7

作者：

Alò, F

Bruni, P

Cavalleri, A

Conti, C

Giorgini, E

Rubini, C

Tosi, G

机构：

[1] Univ Ancona, Clin Chirurgia Vascolare, I-60131 Ancona, Italy

[2] Univ Ancona, Dipartimento Sci Mat & Terra, I-60131 Ancona, Italy

[3] Perkin Elmer Italia, Monza, Italy

[4] Univ Ancona, Ist Anat Patol, I-60131 Ancona, Italy

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2003年 / 651卷

关键词：

biological tissues; infrared spectroscopy; carotid plaques; thyroid gland; biochemical imaging;

D O I：

10.1016/S0022-2860(02)00660-9

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Fourier Transform Infrared Microscopy enables to study small samples by means of high quality spectra. Biochemical and morphological changes in carotid plaques and thyroid tissues have been displayed by drawing three-dimensional chemical maps of the main vibrational modes in regions of interest. A huge number of spectra were collected that allow to point out even subtle changes in the main components. Micro FT-IR spectroscopy is suited for in vivo clinical diagnostics, immunocytochemical analysis and ex vivo histological determinations to establish a suitable protocol for the study of lesions in human tissues, even at an early stage. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：419 / 426

页数：8

共 19 条

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