Veno-occlusive disease in a fetus caused by pyrrolizidine alkaloids of food origin

被引：57

作者：

Rasenack, R

Müller, C

Kleinschmidt, M

Rasenack, J

Wiedenfeld, H

机构：

[1] Univ Freiburg, Univ Frauenklin, DE-79106 Freiburg, Germany

[2] Univ Freiburg, Dept Obstet & Gynaecol, Freiburg, Germany

[3] Univ Freiburg, Dept Paediat, Freiburg, Germany

[4] Univ Freiburg, Dept Pathol, Freiburg, Germany

[5] Univ Freiburg, Dept Hepatol & Gastroenterol, Freiburg, Germany

[6] Univ Bonn, Dept Pharm, Bonn, Germany

来源：

FETAL DIAGNOSIS AND THERAPY | 2003年 / 18卷 / 04期

关键词：

fetal ascites; veno-occlusive disease; pyrrolizidine alkaloids;

D O I：

10.1159/000070799

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We report the occurrence of veno-occlusive disease in a preterm neonate who was symptomatic with hepatomegaly and ascites and was delivered by Caesarean section for threatening fetal asphyxia and died shortly afterwards. Post mortem examination revealed veno-occlusive disease typical for pyrrolizidine alkaloid poisoning. The content of pyrrolizidine alkaloids in the liver could be confirmed. Analysis of a herbal mixture which was used for cooking in the family revealed high amounts of the respective alkaloids clarifying the source of the poison and the causal relationship. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：223 / 225

页数：3

共 20 条

[1] COMFREY HERB TEA-INDUCED HEPATIC VENO-OCCLUSIVE DISEASE [J].