An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds

被引：169

作者：

Raimbault, S

Dridi, S

Denjean, F

Lachuer, J

Couplan, E

Bouillaud, F

Bordas, A

Duchamp, C

Taouis, M

Ricquier, D

机构：

[1] CNRS, Ctr Rech Endocrinol Mol & Dev, F-92190 Meudon, France

[2] INRA, Rech Avicoles Stn, F-37380 Nouzilly, France

[3] CNRS, Lab Physiol Regulat Energet Cellulaires & Mol, F-69622 Villeurbanne, France

[4] INRA, Unite Genet Factorielle, F-78352 Jouy En Josas, France

来源：

BIOCHEMICAL JOURNAL | 2001年 / 353卷

关键词：

bioenergetics; mitochondria; mitochondrial carrier; skeletal muscle;

D O I：

10.1042/0264-6021:3530441

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cDNA of an uncoupling protein (UCP) homologue was obtained by screening a chicken skeletal-muscle library. The predicted 307-amino-acid sequence of avian UCP (avUCP) is 55, 70, 70 and 46% identical with mammalian UCP1, UCP2, and UCP3 and plant UCP respectively. avUCP mRNA expression is restricted to skeletal muscle and its abundance was increased 1.3-fold in a chicken line showing diet-induced thermogenesis, and 3.6- and 2.6-fold in cold-acclimated and glucagon-treated ducklings developing muscle non-shivering thermogenesis respectively. The present data support the implication of avUCP in avian energy expenditure.

引用

页码：441 / 444

页数：4

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