Is the induction of apoptosis the mechanism of the protective effects of TNF alpha in helminth infection?

被引：8

作者：

Garside, P ^{[1
]}

Sands, WA ^{[1
]}

Kusel, JR ^{[1
]}

Hagan, P ^{[1
]}

机构：

[1] UNIV GLASGOW,INST BIOMED & LIFE SCI,GLASGOW,LANARK,SCOTLAND

来源：

PARASITE IMMUNOLOGY | 1996年 / 18卷 / 03期

关键词：

apoptosis; TNF alpha; helminth; TUMOR-NECROSIS-FACTOR; SCHISTOSOMA-MANSONI; INVITRO; ANTIBODY; CELLS; MICE; IL-1; EGG;

D O I：

10.1046/j.1365-3024.1996.d01-66.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumour necrosis factor alpha has been implicated in protective immune responses to a number of parasitic helminths. However, the final effector mechanisms resulting in death or expulsion of the parasite are unclear. Here we suggest that, by employing phylogenetically conserved mechanisms, the mammalian immune system is able to interfere with helminth development directly and that the protective effects of TNF alpha in helminth infections may operate via the induction of parasite apoptosis.

引用

页码：111 / 113

页数：3

共 30 条

[1] TUMOR-NECROSIS-FACTOR-ALPHA RESTORES GRANULOMAS AND INDUCES PARASITE EGG-LAYING IN SCHISTOSOME-INFECTED SCID MICE [J].

AMIRI, P ;

LOCKSLEY, RM ;

PARSLOW, TG ;

SADICK, M ;

RECTOR, E ;

RITTER, D ;

MCKERROW, JH .

NATURE, 1992, 356 (6370) :604-607

[2]

BENBERNOU N, 1992, CLIN EXP IMMUNOL, V88, P264, DOI 10.1111/j.1365-2249.1992.tb03071.x

[3]

CHENSUE SW, 1989, J IMMUNOL, V142, P1281

[4]

DEKOSSODO S, 1992, J EXP MED, V173, P699

[5] RECOGNITION OF APOPTOTIC CELLS BY HUMAN MACROPHAGES - INHIBITION BY A MONOCYTE/MACROPHAGE-SPECIFIC MONOCLONAL-ANTIBODY [J].

FLORA, PK ;

GREGORY, CD .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (11) :2625-2632

[6]

HAQUE A, 1981, J IMMUNOL, V127, P716

[7] C-ELEGANS CELL-SURVIVAL GENE CED-9 ENCODES A FUNCTIONAL HOMOLOG OF THE MAMMALIAN PROTOONCOGENE BCL-2 [J].

HENGARTNER, MO ;

HORVITZ, HR .

CELL, 1994, 76 (04) :665-676

[8] CAENORHABDITIS-ELEGANS GENE CED-9 PROTECTS CELLS FROM PROGRAMMED CELL-DEATH [J].

HENGARTNER, MO ;

ELLIS, RE ;

HORVITZ, HR .

NATURE, 1992, 356 (6369) :494-499

[9] TUMOR NECROSIS FACTOR (TNF) AS A MEDIATOR OF MACROPHAGE HELMINTHOTOXIC ACTIVITY [J].

JAMES, SL ;

GLAVEN, J ;

GOLDENBERG, S ;

MELTZER, MS ;

PEARCE, E .

PARASITE IMMUNOLOGY, 1990, 12 (01) :1-13

[10] EFFECTS OF RECOMBINANT TUMOR-NECROSIS-FACTOR ON ANTIBODY-DEPENDENT EOSINOPHIL-MEDIATED DAMAGE TO SCHISTOSOMA-JAPONICUM LARVAE [J].

JANECHARUT, T ;

HATA, H ;

TAKAHASHI, H ;

YOSHIDA, S ;

SAITO, H ;

KOJIMA, S .

PARASITE IMMUNOLOGY, 1992, 14 (06) :605-616

← 1 2 3 →