Parallel synthesis of pyrazolines on soluble polymer support

被引：25

作者：

Wang, YG ^{[1
]}

Zhang, J ^{[1
]}

Lin, XF ^{[1
]}

Ding, HF ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

SYNLETT | 2003年 / 10期

关键词：

pyrazolines; 1,3-dipolar cycloaddition; soluble polymer; liquid-phase synthesis; polyethylene glycol (PEG);

D O I：

10.1055/s-2003-40863

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and rapid parallel liquid-phase synthesis of pyrazolines has been developed. The one-pot three-components reaction of polyethylene glycol (PEG)-supported acrylate 1, aldehyde 2 and aryl hydrazine 3 in the presence of chloramine-T in methanol gave the corresponding PEG-supported pyrazolines 5. Cleavage from the support under mild conditions afforded pyrazolines 6 in good yields (69-91%) and high purities (91-100%).

引用

页码：1467 / 1468

页数：2

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