A compendium of specific motifs for diagnosing GPCR subtypes

被引：47

作者：

Attwood, TK ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2001年 / 22卷 / 04期

关键词：

D O I：

10.1016/S0165-6147(00)01658-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Analysis of G-protein coupled receptor (GPCR) subtypes has attracted considerable interest because some drugs that act on GPCRs cause therapeutic problems as a result of their failure to differentiate between subtypes. In this article, an extensive compendium of diagnostic 'fingerprints' for GPCR subtypes and their families will be described. These fingerprints offer new opportunities to investigate correlations between specific sequence motifs and ligand binding or G-protein coupling, and are likely to prove valuable both in seeking novel receptors in genome data and in the characterization of orphan receptors.

引用

页码：162 / 165

页数：6

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