In vivo comparison of the osseointegration of vacuum plasma sprayed titanium- and hydroxyapatite-coated implants

被引:41
作者
Aebli, N [1 ]
Krebs, J
Stich, H
Schawalder, P
Walton, M
Schwenke, D
Gruner, H
Gasser, B
Theis, JC
机构
[1] Univ Otago, Dept Orthopaed Surg, Dunedin, New Zealand
[2] Univ Bern, Sch Dent, Bern, Switzerland
[3] Univ Bern, Sch Vet, Bern, Switzerland
[4] Medicoat AG, Magenwil, Switzerland
[5] Dr Robert Mathys Fdn, Bettlach, Switzerland
来源
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2003年 / 66A卷 / 02期
关键词
implant fixation; hydroxyapatite; titanium; osseointegration; vacuum plasma spraying;
D O I
10.1002/jbm.a.10508
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
For the last 15 years, orthopedic implants have been coated with hydroxyapatite (HA) to improve implant fixation. The osteoconductive effect of HA coatings has been demonstrated in experimental and clinical studies. However, there are ongoing developments to improve the quality of HA coatings. The objective of this study was to investigate whether a rough and highly crystalline HA coating applied by vacuum plasma spraying (VPS) had a positive effect on the osseointegration of special, high-grade titanium (Ti) implants with the same surface roughness. Ti alloy implants were coated (VPS) with special, high-grade Ti or HA. The osseointegration of the implants was evaluated by either light microscopy or pullout tests after 1, 2, and 4 weeks of unloaded implantation in the cancellous bone of 18 sheep. The interface shear strength increased significantly over all time intervals. By 4 weeks, values had reached similar to10N/mm(2). However, the difference between the coatings was not significant at any time interval. Direct bone-implant contact was significantly different between the coatings after 2 and 4 weeks, and reached 46% for Ti and 68% for HA implants by 4 weeks. This study indicates that the use of a rough and highly crystalline HA coating, applied by VPS, enhances early osseointegration. Accelerated establishment of secondary implant fixation decreases the risk of early loosening. (C) 2003 Wiley Periodicals, Inc.
引用
收藏
页码:356 / 363
页数:8
相关论文
共 38 条
[1]   BONE INGROWTH INTO WEIGHT-BEARING POROUS FIBER TITANIUM IMPLANTS - MECHANICAL AND BIOCHEMICAL CORRELATIONS [J].
BARTH, E ;
RONNINGEN, H ;
SOLHEIM, LF ;
SAETHREN, B .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1986, 4 (03) :356-361
[2]  
Brossa F., 1993, Bio-Medical Materials and Engineering, V3, P127
[3]   Highly crystalline Mp-1™ hydroxylapatite coating Part I:: In vitro characterization and comparison to other plasma-sprayed hydroxylapatite coatings [J].
Burgess, AV ;
Story, BJ ;
La, D ;
Wagner, WR ;
LeGeros, JP .
CLINICAL ORAL IMPLANTS RESEARCH, 1999, 10 (04) :245-256
[4]   Highly crystalline Mp-1™ hydroxylapatite coating Part II:: In vivo performance on endosseous root implants in dogs [J].
Burgess, AV ;
Story, BJ ;
Wagner, WR ;
Trisi, P ;
Pikos, MA ;
Guttenberg, SA .
CLINICAL ORAL IMPLANTS RESEARCH, 1999, 10 (04) :257-266
[5]   INFLUENCE OF SURFACE CHARACTERISTICS ON BONE INTEGRATION OF TITANIUM IMPLANTS - A HISTOMORPHOMETRIC STUDY IN MINIATURE PIGS [J].
BUSER, D ;
SCHENK, RK ;
STEINEMANN, S ;
FIORELLINI, JP ;
FOX, CH ;
STICH, H .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1991, 25 (07) :889-902
[6]  
Chang YL, 1999, J ORAL MAXIL SURG, V57, P1096
[7]  
COOK SD, 1988, CLIN ORTHOP RELAT R, P225
[8]   HYDROXYLAPATITE COATING OF POROUS IMPLANTS IMPROVES BONE INGROWTH AND INTERFACE ATTACHMENT STRENGTH [J].
COOK, SD ;
THOMAS, KA ;
DALTON, JE ;
VOLKMAN, TK ;
WHITECLOUD, TS ;
KAY, JF .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1992, 26 (08) :989-1001
[9]   STRUCTURAL ARRANGEMENTS AT THE INTERFACE BETWEEN PLASMA-SPRAYED CALCIUM PHOSPHATES AND BONE [J].
DEBRUIJN, JD ;
BOVELL, YP ;
VANBLITTERSWIJK, CA .
BIOMATERIALS, 1994, 15 (07) :543-550
[10]   Direct morphological comparison of vacuum plasma sprayed and detonation gun sprayed hydroxyapatite coatings for orthopaedic applications [J].
Gledhill, HC ;
Turner, IG ;
Doyle, C .
BIOMATERIALS, 1999, 20 (04) :315-322