Automated parallel synthesis of a protected oligosaccharide library based upon the structure of dimeric Lewis X by one-pot sequential glycosylation

被引：40

作者：

Tanaka, H ^{[1
]}

Matoba, N ^{[1
]}

Tsukamoto, H ^{[1
]}

Takimoto, H ^{[1
]}

Yamada, H ^{[1
]}

Takahashi, T ^{[1
]}

机构：

[1] Tokyo Inst Technol, Grad Sch Sci & Technol, Dept Appl Chem, Tokyo 1528552, Japan

来源：

SYNLETT | 2005年 / 05期

关键词：

automated synthesis; glycosyl fluoride; Lewis X; one-pot glycosylation; thioglycoside;

D O I：

10.1055/s-2005-863751

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of a protected dimeric Lewis X epitope by two sequential one-pot glycosylations is described. Combinatorial synthesis of the dimeric Lewis X epitope derivatives by the one-pot glycosylation was accomplished utilizing an automated synthesizer to provide 12-protected oligosaccharides.

引用

收藏

页码：824 / 828

页数：5

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