Mating attenuates aging-associated increase of lipid peroxidation activity in C57BL/6J mice

被引：7

作者：

Oxenkrug, GF

Requintina, PJ

机构：

[1] St Elizabeths Med Ctr, Pineal Res Lab, Dept Psychiat, Brighton, MA 02135 USA

[2] Tufts Univ, Sch Med, Boston, MA 02111 USA

[3] VA Med Ctr, Providence, RI USA

来源：

NEUROPROTECTIVE AGENTS | 2003年 / 993卷

关键词：

lipid peroxidation; aging; mating; C57BI/6J mice; malonaldehyde and 4-hydroxyalkenal (MDA plus HAE);

D O I：

10.1111/j.1749-6632.2003.tb07526.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the frame of the free-radical hypothesis of aging and literature data on increased life span of mated animals, we evaluated brain, kidney, and liver lipid peroxidation in C57B1/6J mice of various ages and compared lipid peroxidation activity in mated and non-mated mice of both genders. An aging-associated increase (from 3 to 12 months of age) of lipid peroxidation, as measured by malonaldehyde and 4-hydroxyalkenals (MDA+HAE) levels, was observed in the liver and kidney, but not in the brain. Tissue MDA + HAE levels were lower in 12-month old mated mice (housed with animals of opposite gender from three to five months of age) than in 12-month old non-mated animals. There were no gender differences in the observed effect. It is suggested that mating might attenuate the increase of lipid peroxidation associated with aging.

引用

页码：161 / 167

页数：7

共 18 条

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