The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers

被引：121

作者：

Cuadros, R

de Garcini, EM

Wandosell, F

Faircloth, G

Fernández-Sousa, JM

Avila, J ^{[1
]}

机构：

[1] Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

[2] PharmaMar USA Inc, Cambridge, MA 02139 USA

[3] PharmaMar, Madrid 28769, Spain

来源：

CANCER LETTERS | 2000年 / 152卷 / 01期

关键词：

spisulosine; cytoskeleton; actin stress fibers; Rho protein;

D O I：

10.1016/S0304-3835(99)00428-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Spisulosine is a novel antiproliferative (antitumoral) compound of marine origin. In this work the molecular target for this toxic agent has been analyzed. In the presence of spisulosine, cultured cells change their morphology, first acquiring a fusiform morphology, and later becoming rounded without focal adhesions. Analysis of the cytoskeleton of treated cells indicate the absence of actin stress fibers. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：23 / 29

页数：7

共 31 条

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