The Search for Unaffected Individuals with Lynch Syndrome: Do the Ends Justify the Means?

被引：123

作者：

Hampel, Heather ^{[1
]}

de la Chapelle, Albert ^{[2
]}

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Dept Internal Med, Div Human Genet, Columbus, OH 43240 USA

[2] Ohio State Univ, Ctr Comprehens Canc, Mol Virol Immunol & Med Genet Dept, Columbus, OH 43240 USA

来源：

CANCER PREVENTION RESEARCH | 2011年 / 4卷 / 01期

关键词：

NONPOLYPOSIS COLORECTAL-CANCER; GENETIC TESTING STRATEGIES; FAMILY-HISTORY; REDUCING MORBIDITY; MORTALITY; RISK;

D O I：

10.1158/1940-6207.CAPR-10-0345

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lynch syndrome is the most common cause of inherited colorectal and endometrial cancers yet it is underrecognized in clinical practice. The relative merits of screening for Lynch syndrome among healthy adults without cancer versus among adults with colorectal or endometrial cancer are discussed in this Perspective article. Newly diagnosed colorectal cancer patients are a much easier target population for screening and this approach leads to more informative genetic test results, at a lower cost in most cases. Cancer Prev Res; 4(1); 1-5. (C) 2011 AACR.

引用

页码：1 / 5

页数：5

共 23 条

[1] Family history-taking in community family practice: Implications for genetic screening [J].

Acheson, LS ;

Wiesner, GL ;

Zyzanski, SJ ;

Goodwin, MA ;

Stange, KC .

GENETICS IN MEDICINE, 2000, 2 (03) :180-185

[2]

[Anonymous], Colorectal cancer facts & figures . 2020‐2022.

[3]

[Anonymous], NAT COMPR CANC NETW

[4]

[Anonymous], GENET MED

[5]

[Anonymous], AHRQ PUBLICATION

[6]

Blumenthal D, 1999, J FAM PRACTICE, V48, P264

[7] Health Benefits and Cost-Effectiveness of Primary Genetic Screening for Lynch Syndrome in the General Population [J].

Dinh, Tuan A. ;

Rosner, Benjamin I. ;

Atwood, James C. ;

Boland, C. Richard ;

Syngal, Sapna ;

Vasen, Hans F. A. ;

Gruber, Stephen B. ;

Burt, Randall W. .

CANCER PREVENTION RESEARCH, 2011, 4 (01) :9-22

[8] Screening for the Lynch syndrome (Hereditary nonpolyposis colorectal cancer). [J].

Hampel, H ;

Frankel, WL ;

Martin, E ;

Arnold, M ;

Khanduja, K ;

Kuebler, P ;

Nakagawa, H ;

Sotamaa, K ;

Prior, TW ;

Westman, J ;

Panescu, J ;

Fix, D ;

Lockman, J ;

Comeras, I ;

de la Chapelle, A ;

Ellison, C ;

Melvin, S ;

Winston, J ;

Adeli, A ;

Burak, W ;

Chadwick, R ;

Elkhatib, I ;

Hemingway, T ;

Jamieson, K ;

Johnson, C ;

LaJeunesse, J ;

Liyanarachchi, S ;

Rangel, P ;

Soble, D ;

Walker, M ;

Wise, T ;

Zhang, Y ;

Schlanger, R ;

Aguilar, P ;

Hura, D ;

Keith, J ;

Kerner, B ;

Lavalle, G ;

Taylor, C ;

Vara, T ;

Zangmeister, J ;

DeVictor, S ;

Hines, L ;

Lindsey, M ;

Madhavan, J ;

Padmanabhan, A ;

Hamelberg, K ;

Niemann, T ;

Behrens, BC ;

Blair, SC .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (18) :1851-1860

[9] Comment on: Screening for lynch syndrome (Hereditary Nonpolyposis colorectal cancer) among endometrial cancer patients [J].

Hampel, Heather ;

Paneseu, Jenny ;

Lockman, Janet ;

Sotamaa, Kaisa ;

Fix, Daniel ;

Comeras, Ilene ;

LaJeunesse, Jennifer ;

Nakagawa, Hidewaki ;

Westman, Judith A. ;

Prior, Thomas W. ;

Clendenning, Mark ;

de la Chapelle, Albert ;

Frankel, Wendy ;

Penzone, Pamela ;

Cohn, David E. ;

Copeland, Larry ;

Eaton, Lynne ;

Fowler, Jeffrey ;

Lombardi, Janet ;

Dunn, Patti ;

Bell, Jeffrey ;

Reid, Gary ;

Lewandowski, George ;

Vaccarello, Luis .

CANCER RESEARCH, 2007, 67 (19) :9603-9603

[10] Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients [J].