A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli

被引：201

作者：

Kolodkin-Gal, Ilana

Hazan, Ronen

Gaathon, Ariel

Carmeli, Shmuel

Engelberg-Kulka, Hanna ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Mol Biol, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Hadassah Med Sch, Core Res Facil, IL-91120 Jerusalem, Israel

[3] Tel Aviv Univ, Sch Chem, IL-69978 Tel Aviv, Israel

来源：

SCIENCE | 2007年 / 318卷 / 5850期

关键词：

D O I：

10.1126/science.1147248

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

mazEF is a toxin-antitoxin module located on many bacterial chromosomes, including those of pathogens. Here, we report that Escherichia coli mazEF-mediated cell death is a population phenomenon requiring a quorum-sensing molecule that we call the extracellular death factor (EDF). Structural analysis revealed that EDF is a linear pentapeptide, Asn-Asn-Trp-Asn-Asn. Each of the five amino acids of EDF is important for its activity.

引用

页码：652 / 655

页数：4

共 27 条

[1] An Escherichia coli chromosomal ''addiction module'' regulated by 3',5'-bispyrophosphate: A model for programmed bacterial cell death [J].