Bone remodeling, energy metabolism, and the molecular clock

被引：98

作者：

Rosen, Clifford J. ^{[1
,2
]}

机构：

[1] Maine Med Ctr, Res Inst, Scarborough, ME 04074 USA

[2] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

CELL METABOLISM | 2008年 / 7卷 / 01期

关键词：

D O I：

10.1016/j.cmet.2007.12.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The adult skeleton is constantly renewed through bone remodeling. Four recent papers (Balclock et al., 2007; Lee et al., 2007; Lundberg et al., 2007; Sato et al., 2007) provide new insights into central and peripheral control of this remodeling sequence. Two of the studies add to our knowledge of the complex hypothalamic modulation of bone turnover mediated by NMU and NPY via the sympathetic nervous system, while the other two focus on the peripheral neural target, the osteoblast, and its regulation by neuropeptides and osteocalcin. These findings support a new paradigm concerning the regulation of bone remodeling and provide a foundation for novel approaches to preventing osteoporosis.

引用

页码：7 / 10

页数：4

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