The vitamin D receptor

被引：34

作者：

Carlberg, Carsten

Seuter, Sabine

机构：

[1] Univ Luxembourg, Life Sci Res Unit, L-1511 Luxembourg, Luxembourg

[2] Univ Kuopio, Dept Biochem, FIN-70211 Kuopio, Finland

来源：

DERMATOLOGIC CLINICS | 2007年 / 25卷 / 04期

关键词：

D O I：

10.1016/j.det.2007.06.004

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The vitamin D endocrine system is known for its essential role in calcium homeostasis and bone metabolism, and induces cell differentiation, inhibits cell growth, controls other hormonal systems, and modulates the immune response. Vitamin D-3 is a prohormone that is taken up by diet or synthesized in ultraviolet radiation-exposed skin and metabolically converted to the active metabolite, 1 alpha,25-dihydroxyvitamin D-3. This nuclear hormone binds with high affinity the nuclear receptor vitamin D receptor. More than 3000 synthetic analogs of 1 alpha,25(OH)(2)D-3 are known. This review aims to provide an overview on vitamin D signaling from the skin perspective.

引用

页码：515 / +

页数：10

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