The initial management of stable angina in Europe, from the Euro Heart Survey - A description of pharmacological management and revascularization strategies initiated within the first month of presentation to a cardiologist in the Euro Heart Survey of Stable Angina

被引:61
作者
Daly, CA
Clemens, F
Sendon, JLL
Tavazzi, L
Boersma, E
Danchin, N
Delahaye, F
Gitt, A
Julian, D
Mulcahy, D
Ruzyllo, W
Thygesen, K
Verheugt, F
Fox, KM
机构
[1] Royal Brompton Hosp, London SW3 6NP, England
[2] London Sch Hyg & Trop Med, London WC1, England
[3] Hosp Univ Gregorio Maranon, Madrid, Spain
[4] Policlin San Matteo, I-27100 Pavia, Italy
[5] Hop Europeen Georges Pompidou, Paris, France
[6] Hop Cardiovasc & Pneumol Louis Pradel, Lyon, France
[7] Herzzentrum Ludwigshafen, Ludwigshafen, Germany
[8] Newcastle Univ, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[9] Adelaide & Meath Inc Natl Childrens Hosp, Dublin, Ireland
[10] Inst Cardiol, Warsaw, Poland
[11] Aarhus Univ Hosp, DK-8000 Aarhus, Denmark
[12] Univ St Radboud, Ctr Med, Nijmegen, Netherlands
关键词
stable angina; pharmacological therapy; secondary prevention; coronary revascularization;
D O I
10.1093/eurheartj/ehi109
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims In order to assess adherence to guidelines and international variability in management, the Euro Heart Survey of Newly Presenting Angina prospectively studied medical therapy, percutaneous coronary intervention (PCI), and surgery in patients with new-onset stable angina in Europe. Methods and results Consecutive patients, 3779 in total, with a clinical diagnosis of stable angina by a cardiologist were enrolled. After initial assessment by a cardiologist, 78% were treated with aspirin, 48% with a statin, and 67% with a beta-blocker. ACE-inhibitors were prescribed by the cardiologist in 37% overall. Revascularization rates were low, with only 501 (13%) patients having PCl or coronary bypass surgery performed or planned. However, when restricted to patients with coronary disease documented within 4 weeks of assessment, over 50% had revascularization performed or planned. Among other factors, the national rate of angiography and availability of invasive facilities significantly predicted the likelihood of revascularization, OR 2.4 and 2.0, respectively. Conclusion This survey shows a shortfall between guidelines and practice with regard to the use of evidence-based drug therapy and evidence that revascularization rates are strongly influenced by non-clinical, in addition to clinical, factors.
引用
收藏
页码:1011 / 1022
页数:12
相关论文
共 31 条
  • [1] 10-YEAR FOLLOW-UP OF SURVIVAL AND MYOCARDIAL-INFARCTION IN THE RANDOMIZED CORONARY-ARTERY SURGERY STUDY
    ALDERMAN, EL
    BOURASSA, MG
    COHEN, LS
    DAVIS, KB
    KAISER, GG
    KILLIP, T
    MOCK, MB
    PETTINGER, M
    ROBERTSON, TL
    [J]. CIRCULATION, 1990, 82 (05) : 1629 - 1646
  • [2] Medical treatment of patients with stable angina pectoris referred for coronary angiography: Failure of treatment or failure to treat
    Carasso, S
    Markiewicz, W
    [J]. CLINICAL CARDIOLOGY, 2002, 25 (09) : 436 - 441
  • [3] Silent myocardial ischemia
    Cohn, PF
    Fox, KM
    Daly, C
    [J]. CIRCULATION, 2003, 108 (10) : 1263 - 1277
  • [4] Collins R, 2002, LANCET, V360, P7, DOI 10.1016/S0140-6736(02)09327-3
  • [5] DALY CA, 2005, IN PRESS EUR HEART J
  • [6] Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trial
    Dargie, HJ
    Ford, I
    Fox, KM
    Hillis, WS
    [J]. LANCET, 2002, 359 (9314) : 1269 - 1275
  • [7] Dargie HJ, 1996, EUR HEART J, V17, P104
  • [8] The ENACT study: a pan-European survey of acute coronary syndromes
    Fox, KAA
    Cokkinos, DV
    Deckers, J
    Keil, U
    Maggioni, A
    Steg, G
    [J]. EUROPEAN HEART JOURNAL, 2000, 21 (17) : 1440 - 1449
  • [9] Fox KM, 2003, LANCET, V362, P782
  • [10] GANDHI MM, 1995, BRIT HEART J, V73, P193