Acetylcholinesterase - A multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease

被引：104

作者：

Greenblatt, HM

Dvir, H

Silman, I

Sussman, JL ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Struct, IL-76100 Rehovot, Israel

[2] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2003年 / 20卷 / 03期

关键词：

Alzheimer's disease; anticholinesterase; cholinergic deficiency; drug design; Torpedo;

D O I：

10.1385/JMN:20:3:369

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of Torpedo californica acetylcholinesterase is examined in complex with several inhibitors that are either in use or under development for treating Alzheimer's disease. The noncovalent inhibitors vary greatly in their structures and bind to different sites of the enzyme, offering many different starting points for future drug design.

引用

页码：369 / 383

页数：15

共 79 条

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ALDRIDGE WN, 1972, ENZYME IMHIBITORS SU

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ASHANI Y, 1994, MOL PHARMACOL, V45, P555

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