Systemic and mucosal immune responses in young children and adults after parenteral influenza vaccination

被引:58
作者
El-Madhun, AS [1 ]
Cox, RJ
Soreide, A
Olofsson, J
Haaheim, LR
机构
[1] Univ Bergen, Dept Mol Biol, N-5020 Bergen, Norway
[2] Univ Bergen, Dept Otolaryngol Head & Neck Surg, N-5020 Bergen, Norway
关键词
D O I
10.1086/515656
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The effect of natural mucosal priming on systemic and mucosal immune responses was investigated in young children after parenteral influenza vaccination, Eighteen young children and 8 adults were vaccinated with trivalent influenza vaccine at various time intervals before tonsillectomy, The influenza-specific IgG, IgA, and IgM immune responses were examined in tonsillar lymphocytes and frequent samples of peripheral blood and oral fluid, Young children were divided into primed and unprimed groups on the basis of presence of prevaccination serum antibodies. In peripheral blood, adults and primed children had significantly higher Ige and IgA antibody responses than did unprimed children. Irrespective of priming, children elicited weaker IgA responses than adults in both tonsils and oral fluid. While natural priming was essential to elicit strong systemic response in young children after parenteral influenza vaccination, it did not influence the local responses, which were significantly lower in both primed and unprimed children than in adults.
引用
收藏
页码:933 / 939
页数:7
相关论文
共 18 条
  • [1] BERNSTEIN JM, 1988, ACTA OTO-LARYNGOL, P153
  • [2] IMMUNOGLOBULIN-G, IMMUNOGLOBULIN-A AND IMMUNOGLOBULIN-M RESPONSE TO INFLUENZA VACCINATION IN DIFFERENT AGE-GROUPS - EFFECTS OF PRIMING AND BOOSTING
    BEYER, WEP
    VANDERLOGT, JTM
    VANBEEK, R
    MASUREL, N
    [J]. JOURNAL OF HYGIENE, 1986, 96 (03) : 513 - 522
  • [3] PARENTERAL INFLUENZA VACCINATION INDUCES A RAPID SYSTEMIC AND LOCAL IMMUNE-RESPONSE
    BROKSTAD, KA
    COX, RJ
    OLOFSSON, J
    JONSSON, R
    LARS, R
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (01) : 198 - 203
  • [4] IGA, IGA SUBCLASSES, AND SECRETORY COMPONENT LEVELS IN ORAL FLUID COLLECTED FROM SUBJECTS AFTER PARENTERAL INFLUENZA VACCINATION
    BROKSTAD, KA
    COX, RJ
    OXFORD, JS
    HAAHEIM, LR
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (04) : 1072 - 1074
  • [5] RESISTANCE OF ADULTS TO CHALLENGE WITH INFLUENZA-A WILD-TYPE VIRUS AFTER RECEIVING LIVE OR INACTIVATED VIRUS-VACCINE
    CLEMENTS, ML
    BETTS, RF
    TIERNEY, EL
    MURPHY, BR
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1986, 23 (01) : 73 - 76
  • [6] SERUM AND NASAL WASH ANTIBODIES ASSOCIATED WITH RESISTANCE TO EXPERIMENTAL CHALLENGE WITH INFLUENZA-A WILD-TYPE VIRUS
    CLEMENTS, ML
    BETTS, RF
    TIERNEY, EL
    MURPHY, BR
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1986, 24 (01) : 157 - 160
  • [7] AN EARLY HUMORAL IMMUNE-RESPONSE IN PERIPHERAL-BLOOD FOLLOWING PARENTERAL INACTIVATED INFLUENZA VACCINATION
    COX, RJ
    BROKSTAD, KA
    ZUCKERMAN, MA
    WOOD, JM
    HAAHEIM, LR
    OXFORD, JS
    [J]. VACCINE, 1994, 12 (11) : 993 - 999
  • [8] PRESENCE OF NONMATERNAL ANTIBODIES IN NEWBORNS OF MOTHERS WITH ANTIBODY DEFICIENCIES
    HAHNZORIC, M
    CARLSSON, B
    BJORKANDER, J
    OSTERHAUS, ADME
    MELLANDER, L
    [J]. PEDIATRIC RESEARCH, 1992, 32 (02) : 150 - 154
  • [9] COMPARISON OF LONG-TERM SYSTEMIC AND SECRETORY ANTIBODY-RESPONSES IN CHILDREN GIVEN LIVE, ATTENUATED, OR INACTIVATED INFLUENZA-A VACCINE
    JOHNSON, PR
    FELDMAN, S
    THOMPSON, JM
    MAHONEY, JD
    WRIGHT, PF
    [J]. JOURNAL OF MEDICAL VIROLOGY, 1985, 17 (04) : 325 - 335
  • [10] Kantele A, 1997, J IMMUNOL, V158, P574