CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke

被引：97

作者：

Ren, Xuefang ^{[1
,2
]}

Akiyoshi, Kozaburo ^{[2
]}

Vandenbark, Arthur A. ^{[1
,3
,4
]}

Hurn, Patricia D. ^{[2
,3
]}

Offner, Halina ^{[1
,2
,3
]}

机构：

[1] Portland VA Med Ctr, R&D 31, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Anesthesiol & Perioperat Med, Portland, OR 97201 USA

[3] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA

[4] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97201 USA

来源：

METABOLIC BRAIN DISEASE | 2011年 / 26卷 / 01期

关键词：

Cerebral ischemia; T lymphocyte; T regulatory cells; Middle cerebral artery occlusion; Stroke;

D O I：

10.1007/s11011-010-9226-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3(DTR) mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.

引用

页码：87 / 90

页数：4

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