Rab GTPases and the unusual secretory pathway of Plasmodium

被引：45

作者：

Ward, GE

Tilney, LG

Langsley, G

机构：

[1] UNIV PENN, DEPT BIOL, PHILADELPHIA, PA 19104 USA

[2] INST PASTEUR, DEPT IMMUNOL, URA CNRS 1960, UNIT EXPT PARASITOL, F-75015 PARIS, FRANCE

来源：

PARASITOLOGY TODAY | 1997年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0169-4758(96)10080-6

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

A detailed analysis of some of the unusual features of secretory protein trafficking in Plasmodium has been hindered by the paucity of markers available for identifying the different compartments of the parasite's secretory apparatus. Gary Ward, Lew Tilney and Gordon Langsley here outline what is currently known about the secretory pathways of Plasmodium falciparum, and discuss how the recent description of a family of parasite rab genes is being used to generate a set of compartment-specific markers. They illustrate this point by describing studies with PfRab6, an established Golgi marker in other eukaryotic cells, which argue in favor of a functional Golgi in Plasmodium spp.

引用

收藏

页码：57 / 62

页数：6

相关论文

共 40 条

[1] A Plasmodium falciparum homologue of a rab specific GDP dissociation inhibitor [J].

Attal, G ;

Langsley, G .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1996, 79 (01) :91-95

[2] THE ROLE OF THE CYTOSKELETON IN PLASMODIUM-FALCIPARUM MEROZOITE BIOLOGY - AN ELECTRON-MICROSCOPIC VIEW [J].

BANNISTER, LH ;

MITCHELL, GH .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1995, 89 (02) :105-111

[3] A MINIMALIST VIEW OF THE SECRETORY PATHWAY IN PLASMODIUM-FALCIPARUM [J].

BANTING, G ;

BENTING, J ;

LINGELBACH, K .

TRENDS IN CELL BIOLOGY, 1995, 5 (09) :340-343

[4] CLONING THE PLASMODIUM-FALCIPARUM GENE ENCODING PFEMP1, A MALARIAL VARIANT ANTIGEN AND ADHERENCE RECEPTOR ON THE SURFACE OF PARASITIZED HUMAN ERYTHROCYTES [J].

BARUCH, DI ;

PASLOSKE, BL ;

SINGH, HB ;

BI, XH ;

MA, XC ;

FELDMAN, M ;

TARASCHI, TF ;

HOWARD, RJ .

CELL, 1995, 82 (01) :77-87

[5] CALNEXIN - A MEMBRANE-BOUND CHAPERONE OF THE ENDOPLASMIC-RETICULUM [J].

BERGERON, JJM ;

BRENNER, MB ;

THOMAS, DY ;

WILLIAMS, DB .

TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (03) :124-128

[6] BREFELDIN-A INHIBITS PROTEIN SECRETION AND PARASITE MATURATION IN THE RING STAGE OF PLASMODIUM-FALCIPARUM [J].

CRARY, JL ;

HALDAR, K .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1992, 53 (1-2) :185-192

[7] Identification of a family of Rab G-proteins in Plasmodium falciparum and a detailed characterisation of pfrab6 [J].

deCastro, FA ;

Ward, GE ;

Jambou, R ;

Attal, G ;

Mayau, V ;

Jaureguiberry, G ;

BraunBreton, C ;

Chakrabarti, D ;

Langsley, G .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1996, 80 (01) :77-88

[8] GLYCOSYLATION REACTIONS IN PLASMODIUM-FALCIPARUM, TOXOPLASMA-GONDII, AND TRYPANOSOMA-BRUCEI-BRUCEI PROBED BY THE USE OF SYNTHETIC PEPTIDES [J].

DIECKMANNSCHUPPERT, A ;

BAUSE, E ;

SCHWARZ, RT .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1994, 1199 (01) :37-44

[9] STUDIES ON O-GLYCANS OF PLASMODIUM-FALCIPARUM-INFECTED HUMAN ERYTHROCYTES - EVIDENCE FOR O-GLCNAC AND O-GLCNAC-TRANSFERASE IN MALARIA PARASITES [J].

DIECKMANNSCHUPPERT, A ;

BAUSE, E ;

SCHWARZ, RT .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 216 (03) :779-788

[10] PARASITE-REGULATED MEMBRANE-TRANSPORT PROCESSES AND METABOLIC CONTROL IN MALARIA-INFECTED ERYTHROCYTES [J].

ELFORD, BC ;

COWAN, GM ;

FERGUSON, DJP .

BIOCHEMICAL JOURNAL, 1995, 308 :361-374

← 1 2 3 4 →