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The proteasome

被引：66
作者：
Baumeister, W
Lupas, A
机构：
[1] Max-Planck-Inst. für Biochemie, Department of Structural Biology
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 02期
关键词：
D O I：
10.1016/S0959-440X(97)80036-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The proteasome is a macromolecular assembly that is designed to confine proteolytic activity to an inner cavity. Access to the central proteolytic nanocompartment is restricted to unfolded proteins, which necessitates a functional coupling of the 20S proteasome to a substrate-recognition and unfolding machinery. Significant progress has been made during the past two years in elucidating the structural principles and the enzymatic mechanism of the 20S proteasome.
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页码：273 / 278
页数：6
相关论文
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