IFITM Proteins Restrict Antibody-Dependent Enhancement of Dengue Virus Infection

被引：43

作者：

Chan, Ying Kai ^{[1
]}

Huang, I-Chueh ^{[1
]}

Farzan, Michael ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, New England Primate Res Ctr, Dept Microbiol & Immunobiol, Southborough, MA 01772 USA

来源：

PLOS ONE | 2012年 / 7卷 / 03期

关键词：

WEST NILE VIRUS; HEMORRHAGIC-FEVER; HUMAN-CELLS;

D O I：

10.1371/journal.pone.0034508

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interferon-inducible transmembrane (IFITM) proteins restrict the entry processes of several pathogenic viruses, including the flaviviruses West Nile virus and dengue virus (DENV). DENV infects cells directly or via antibody-dependent enhancement (ADE) in Fc-receptor-bearing cells, a process thought to contribute to severe disease in a secondary infection. Here we investigated whether ADE-mediated DENV infection bypasses IFITM-mediated restriction or whether IFITM proteins can be protective in a secondary infection. We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections.

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