Unusual cytotoxicities of 5-(acylethynyl)-1-(2-hydroxyethoxy)methyluracils

被引：26

作者：

Kundu, NG ^{[1
]}

Mahanty, JS ^{[1
]}

Spears, CP ^{[1
]}

机构：

[1] UNIV SO CALIF,KENNETH NORRIS JR COMPREHENS CANC CTR,CANC RES LAB,LOS ANGELES,CA 90033

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(96)00256-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

5-(Acylethynyl)-1-(2-hydroxyethoxy)methyl uracils (2)-(6) were synthesised in excellent yields from 1-(2-acetoxyethoxy)methyl-5-iodouracil (7) utilising palladium-copper catalysed reactions. Compounds (2)-(5) were shown to be highly active against CCRF-CEM (IC50 0.6-1.6 mu M) and L1210/0 cells (IC50 0.7-2.2 mu M) in culture, and thus exhibit greater activity than their parent bases. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1497 / 1502

页数：6

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