Hedgehog signalling in cancer formation and maintenance

被引：704

作者：

di Magliano, MP ^{[1
]}

Hebrok, M ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Ctr Diabet, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 12期

关键词：

D O I：

10.1038/nrc1229

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Hedgehog signalling pathway is essential for numerous processes during embryonic development. Members of this family of secreted proteins control cell proliferation, differentiation and tissue patterning in a dose-dependent manner. Although the overall activity of the pathway is diminished after embryogenesis, recent reports show that the pathway remains active in some adult tissues, including adult stem cells in the brain and skin. There is also evidence that uncontrolled activation of the pathway results in specific types of cancer.

引用

页码：903 / 911

页数：9

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