Occlusal Disharmony Increases Amyloid-β in the Rat Hippocampus

被引：30

作者：

Ekuni, D. ^{[1
]}

Tomofuji, T. ^{[1
]}

Irie, K. ^{[1
]}

Azuma, T. ^{[1
]}

Endo, Y. ^{[1
]}

Kasuyama, K. ^{[1
]}

Morita, M. ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Prevent Dent, Kita Ku, Okayama 7008558, Japan

来源：

NEUROMOLECULAR MEDICINE | 2011年 / 13卷 / 03期

关键词：

Amyloid-beta; Corticosterone; Hippocampus; Occlusion; Psychological stress; ALZHEIMERS-DISEASE; A-BETA; MOUSE MODEL; RECEPTOR EXPRESSION; TOOTH LOSS; APOPTOSIS; STRESS; MEMORY; NEURODEGENERATION; GLUCOCORTICOIDS;

D O I：

10.1007/s12017-011-8151-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amyloid-beta plays a causative role in Alzheimer's disease. Occlusal disharmony causes chronic psychological stress, and psychological stress increases amyloid-beta accumulation. The purpose of the present study was to investigate whether occlusal disharmony-induced psychological stress affects the accumulation of amyloid-beta and its related gene expressions in the rat hippocampus. Eight-week-old male Wistar rats (n = 18) were divided into three groups of six rats each: (1) a control group that received no treatment for 8 weeks; (2) an occlusal disharmony group that underwent cutoff maxillary molar cusps for 8 weeks; and (3) a recovered group that underwent cutoff maxillary molar cusps for 4 weeks followed by recovery for 4 weeks. Occlusal disharmony increased plasma corticosterone levels in a time-dependent manner. Levels of amyloid-beta 40 and 42, glucocorticoid receptor (Gr) protein, and cleaved caspase 3 (Casp3) as well as gene expressions of amyloid precursor protein, beta-secretase, Casp3, and Gr in the hippocampus in the occlusal disharmony group were significantly higher than those in the control group (P < 0.016). These findings were significantly improved by recovery of occlusion (P < 0.016). These results indicate that psychological stress induced by occlusal disharmony reversibly induces amyloid-beta 40 and 42 in the rat hippocampus through the glucocorticoid signal.

引用

页码：197 / 203

页数：7

共 40 条

[1] Multiple caspases are involved in β-amyloid-induced neuronal apoptosis [J].