Gene silencing by the thyroid hormone receptor

被引：25

作者：

Eckey, M ^{[1
]}

Moehren, U ^{[1
]}

Baniahmad, A ^{[1
]}

机构：

[1] Univ Giessen, Genet Inst, D-35392 Giessen, Germany

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2003年 / 213卷 / 01期

关键词：

gene silencing; thyroid hormone receptors; corepressors;

D O I：

10.1016/j.mce.2003.10.026

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The thyroid hormone receptors (TR) are able to bind DNA and to repress transcription in the absence of thyroid hormone. This repression function is an important feature of TRs as aberrant silencing can lead to severe diseases and developmental abnormalities. TR utilizes different mechanisms to achieve repression of target genes including the recruitment of cofactors called corepressors; and interference with the basal transcriptional machinery. Recent studies have revealed an important role of chromatin in TR silencing involving different histone modifications and the responsible enzymes. Furthermore, the transcriptional properties of TR depend on the type of the TR DNA-binding elements. This review will focus on the molecular basis of gene silencing by TR and diseases caused by aberrant functioning. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：13 / 22

页数：10

共 58 条

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