Wnt7b regulates placental development in mice

被引：119

作者：

Parr, BA ^{[1
]}

Cornish, VA ^{[1
]}

Cybulsky, MI ^{[1
]}

McMahon, AP ^{[1
]}

机构：

[1] Univ Colorado, Boulder, CO 80309 USA

来源：

DEVELOPMENTAL BIOLOGY | 2001年 / 237卷 / 02期

关键词：

Wnt7b; placenta; chorion; alpha; 4; integrin;

D O I：

10.1006/dbio.2001.0373

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Secreted Wnt proteins regulate many developmental processes in multicellular organisms. We have generated a targeted mutation in the mouse Wnt7b gene. Homozygous Wnt7b mutant mice die at midgestation stages as a result of placental abnormalities. Wnt7b expression in the chorion is required for fusion of the chorion and allantois during placental development. The alpha4 integrin protein, required for chorioallantoic fusion, is not expressed by cells in the mutant chorion. Wnt7b also is required for normal organization of cells in the chorionic plate. Thus, Wnt7b signaling is central to the early stages of placental development in mammals. (C) 2001 Academic Press.

引用

页码：324 / 332

页数：9

共 26 条

[1] CHARACTERIZATION OF PROLIFERIN-RELATED PROTEIN [J].