Biosynthesis of isoprenoids in Escherichia coli:: stereochemistry of the reaction catalyzed by isopentenyl diphosphate:dimethylallyl diphosphate isomerase

被引:25
作者
Leyes, AE [1 ]
Baker, JA [1 ]
Hahn, FM [1 ]
Poulter, CD [1 ]
机构
[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA
关键词
D O I
10.1039/a900621d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) catalyzed by E. coli and S. pombe IPP isomerase proceeds with removal of the pro-R proton at C2 of IPP and addition of a water-derived proton to the re face of the C2-C3 double bond in DMAPP; this is the same stereochemistry observed for S. cerevisiae and rat liver enzymes.
引用
收藏
页码:717 / 718
页数:2
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