Biosynthesis of isoprenoids in Escherichia coli:: stereochemistry of the reaction catalyzed by isopentenyl diphosphate:dimethylallyl diphosphate isomerase

被引：25

作者：

Leyes, AE ^{[1
]}

Baker, JA ^{[1
]}

Hahn, FM ^{[1
]}

Poulter, CD ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 08期

关键词：

D O I：

10.1039/a900621d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) catalyzed by E. coli and S. pombe IPP isomerase proceeds with removal of the pro-R proton at C2 of IPP and addition of a water-derived proton to the re face of the C2-C3 double bond in DMAPP; this is the same stereochemistry observed for S. cerevisiae and rat liver enzymes.

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收藏

页码：717 / 718

页数：2

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