Effects of Aging on Angiogenesis

被引：238

作者：

Lahteenvuo, Johanna ^{[1
,2
]}

Rosenzweig, Anthony ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Cardiovasc, Boston, MA 02215 USA

[2] Univ Eastern Finland, AI Virtanen Inst, Kuopio, Finland

来源：

CIRCULATION RESEARCH | 2012年 / 110卷 / 09期

基金：

美国国家卫生研究院;

关键词：

aging; angiogenesis; NITRIC-OXIDE SYNTHASE; ENDOTHELIAL GROWTH-FACTOR; TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA; RANDOMIZED CONTROLLED-TRIAL; TELOMERASE REVERSE-TRANSCRIPTASE; CORONARY-ARTERY-DISEASE; LOWER-LIMB ISCHEMIA; OXIDATIVE STRESS; SKELETAL-MUSCLE; PROGENITOR CELLS;

D O I：

10.1161/CIRCRESAHA.111.246116

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of both cardiovascular diseases and their adverse sequelae in the elderly. Angiogenesis is both an essential adaptive response to physiological stress and an endogenous repair mechanism after ischemic injury. In addition, induction of angiogenesis is a promising therapeutic approach for ischemic diseases. For these reasons, understanding the basis of age-related impairment of angiogenesis and endothelial function has important implications for understanding and managing cardiovascular disease. In this review, we discuss the molecular mechanisms that contribute to impaired angiogenesis in the elderly and potential therapeutic approaches to improving vascular function and angiogenesis in aging patients. (Circ Res. 2012;110:1252-1263.)

引用

页码：1252 / 1263

页数：12

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