No Association Between CALHM1 Variation and Risk of Alzheimer Disease

被引：36

作者：

Minster, Ryan L. ^{[1
]}

Demirci, F. Yesim ^{[1
]}

DeKosky, Steven T. ^{[2
]}

Kamboh, M. Ilyas ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Human Genet, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Dept Neurol, Sch Med, Pittsburgh, PA 15261 USA

来源：

HUMAN MUTATION | 2009年 / 30卷 / 04期

关键词：

Alzheimer disease; CALHM1; genetic; association; POLYMORPHISM;

D O I：

10.1002/humu.20989

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A polymorphism in the calcium homeostasis modulator 1 gene (CALHM1) has recently been associated with risk of late-onset Alzheimer disease. We examined this variant (rs2986017) in 945 Caucasian Americans with late-onset Alzheimer disease and 875 age-matched Caucasian American controls. No association with risk of late-onset Alzheimer disease (p = 0.368 for genotypes; p = 0.796 for alleles) was observed in our sample. However, a potential modest association of minor allele homozygosity (TT) with an earlier age-at-onset was seen (p = 0.034). (C) 2009 Wiley-Liss, Inc.

引用

页码：E566 / E569

页数：4

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