Origin and functional specializations of DC subsets in the lung

被引：60

作者：

Plantinga, Maud ^{[1
]}

Hammad, Hamida ^{[1
]}

Lambrecht, Bart N. ^{[1
,2
]}

机构：

[1] Univ Ghent, Dept Resp Dis, Lab Immunoregulat & Mucosal Immunol, B-9000 Ghent, Belgium

[2] Erasmus Univ, Dept Pulm Med, Med Ctr, Rotterdam, Netherlands

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2010年 / 40卷 / 08期

关键词：

PLASMACYTOID DENDRITIC CELLS; BLOOD MONOCYTE SUBSETS; INHALED ANTIGEN; INFLUENZA-VIRUS; TH2; RESPONSES; AIRWAY INFLAMMATION; ADAPTIVE IMMUNITY; MOUSE MODEL; LYMPH-NODE; T-CELLS;

D O I：

10.1002/eji.201040562

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lung DC bridge innate and adaptive immunity, and depending on the context, induce Th1, Th2 or Th17 response, to optimally clear infections. Conversely, lung DC can also prevent overt and harmful immune responses to harmless inhaled antigens via induction of Treg or via induction of neutralizing mucosal IgA antibodies. Here, we propose that these functions are not the result of a single population of DC, and instead, subsets of DC perform specialized functions.

引用

页码：2112 / 2118

页数：7

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