Fludarabine-based stem cell transplantation protocol for Fanconi's anaemia in myelodysplastic transformation

被引：20

作者：

McCloy, M ^{[1
]}

Almeida, A ^{[1
]}

Daly, P ^{[1
]}

Vulliamy, T ^{[1
]}

Roberts, IAG ^{[1
]}

Dokal, I ^{[1
]}

机构：

[1] Hammersmith Hosp, Dept Haematol, London W12 0NN, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 112卷 / 02期

关键词：

Fanconi's anaemia; myelodysplasia; stem cell transplantation; fludarabine;

D O I：

10.1046/j.1365-2141.2001.02585.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Allogeneic stem cell transplantation (SCT) represents the treatment of choice for severe bone marrow (BM) failure in patients with Fanconi's anaemia (FA). However, for FA patients developing leukaemic or myelodysplastic transformation, the results of SCT are much less encouraging. We present a 17-year-old girl with myelodysplastic transformation of FA (refractory anaemia with excess blasts) and oculocutaneous albinism, who was treated by sibling SCT using conditioning with fludarabine, cyclophosphamide (CY) and anti-lymphocyte globulin (ALG). She had rapid engraftment with no toxicity and no graft-versus-host disease (GVHD). Twenty-two months after SCT, she had 100% donor chimaerism on Southern blot analysis.

引用

页码：427 / 429

页数：3

共 12 条

[1]

AUERBACH AD, 1998, GENETIC BASIS HUMAN, P317

[2]

Boulad F, 1999, BLOOD, V94, p560A

[3] Malignancies after marrow transplantation for aplastic anemia and Fanconi anemia: A joint Seattle and Paris analysis of results in 700 patients [J].

Deeg, HJ ;

Socie, G ;

Schoch, G ;

HenryAmar, M ;

Witherspoon, RP ;

Devergie, A ;

Sullivan, KM ;

Gluckman, E ;

Storb, R .

BLOOD, 1996, 87 (01) :386-392

[4]

Dokal IS, 1996, BRIT J HAEMATOL, V94, P423

[5] Marrow transplantation for Fanconi anaemia: Conditioning with reduced doses of cyclophosphamide without radiation [J].

Flowers, MED ;

Zanis, J ;

Pasquini, R ;

Deeg, HJ ;

Ribeiro, R ;

Longton, G ;

Medeiros, CR ;

Doney, K ;

Sanders, J ;

Bryant, E ;

Hansen, J ;

Sullivan, KM ;

Appelbaum, F ;

Thomas, ED ;

Storb, R .

BRITISH JOURNAL OF HAEMATOLOGY, 1996, 92 (03) :699-706

[6] BONE-MARROW TRANSPLANTATION IN FANCONI ANEMIA [J].

GLUCKMAN, E ;

DEVERGIE, A ;

SCHAISON, G ;

BUSSEL, A ;

BERGER, R ;

SOHIER, J ;

BERNARD, J .

BRITISH JOURNAL OF HAEMATOLOGY, 1980, 45 (04) :557-564

[7]

Guardiola P, 1998, BONE MARROW TRANSPL, V21, pS24

[8] A fludarabine-based protocol for bone marrow transplantation in Fanconi's anemia [J].

Kapelushnik, J ;

Or, R ;

Slavin, S ;

Nagler, A .

BONE MARROW TRANSPLANTATION, 1997, 20 (12) :1109-1110

[9] Intermediate-dose busulfan and cyclophosphamide as a conditioning regimen for bone marrow transplantation in a case of Fanconi anemia in myelodysplastic transformation [J].

Maschan, AA ;

Kryzanovskii, OI ;

Yourlova, MI ;

Skorobogatova, EV ;

Pashanov, ED ;

Potapova, YE ;

Timonova, LA ;

Bogatcheva, NY ;

Samochatova, EV ;

Roumjantzev, AG .

BONE MARROW TRANSPLANTATION, 1997, 19 (04) :385-387

[10] ISOLATION AND MAPPING OF A POLYMORPHIC DNA-SEQUENCE PYNH24 ON CHROMOSOME-2 [J].

NAKAMURA, Y ;

GILLILAN, S ;

OCONNELL, P ;

LEPPERT, M ;

LATHROP, GM ;

LALOUEL, JM ;

WHITE, R .

NUCLEIC ACIDS RESEARCH, 1987, 15 (23) :10073-10073

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