Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons

被引：43

作者：

Pisani, A ^{[1
]}

Bonsi, P

Centonze, D

Bernardi, G

Calabresi, P

机构：

[1] Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, Rome, Italy

[2] IRCCS, Fdn S Lucia, Rome, Italy

来源：

NEUROPHARMACOLOGY | 2001年 / 40卷 / 03期

关键词：

metabotropic glutamate receptor; striatum; electrophysiology; mGluRs; cholinergic interneurons;

D O I：

10.1016/S0028-3908(00)00184-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The group I mGluR agonist (S)- 3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 agonist 2-chloro-5-hydroxyphenylglycine both induced a membrane depolarisation of striatal cholinergic interneurons. The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：460 / 463

页数：4

共 9 条

[1] Metabotropic glutamate receptors and cell-type-specific vulnerability in the striatum: Implication for ischemia and Huntington's disease [J].

Calabresi, P ;

Centonze, D ;

Pisani, A ;

Bernardi, G .

EXPERIMENTAL NEUROLOGY, 1999, 158 (01) :97-108

[2] Acetylcholine-mediated modulation of striatal function [J].

Calabresi, P ;

Centonze, D ;

Gubellini, P ;

Pisani, A ;

Bernardi, G .

TRENDS IN NEUROSCIENCES, 2000, 23 (03) :120-126

[3] NEUROTRANSMITTERS AND NEUROMODULATORS IN THE BASAL GANGLIA [J].

GRAYBIEL, AM .

TRENDS IN NEUROSCIENCES, 1990, 13 (07) :244-254

[4] Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function [J].

Kaneko, S ;

Hikida, T ;

Watanabe, D ;

Ichinose, H ;

Nagatsu, T ;

Kreitman, RJ ;

Pastan, I ;

Nakanishi, S .

SCIENCE, 2000, 289 (5479) :633-637

[5]

KAWAGUCHI Y, 1993, J NEUROSCI, V13, P4908

[6] Electrophysiological recordings and calcium measurements in striatal large aspiny interneurons in response to combined O2/glucose deprivation [J].

Pisani, A ;

Calabresi, P ;

Centonze, D ;

Marfia, GA ;

Bernardi, G .

JOURNAL OF NEUROPHYSIOLOGY, 1999, 81 (05) :2508-2516

[7] Suppression of K+ conductance by metabotropic glutamate receptor in acutely dissociated large cholinergic neurons of rat caudate putamen [J].

Takeshita, Y ;

Harata, N ;

Akaike, N .

JOURNAL OF NEUROPHYSIOLOGY, 1996, 76 (03) :1545-1558

[8] Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons [J].

Tallaksen-Greene, SJ ;

Kaatz, KW ;

Romano, C ;

Albin, RL .

BRAIN RESEARCH, 1998, 780 (02) :210-217

[9]

Tehrani A, 2000, INVEST OPHTH VIS SCI, V41, P314

← 1 →