Amplification of dynamic chiral crown ether complexes during cyclic acetal formation

The dynamic duo: A more than tenfold increase in the yield of the chiral macropolycyclic polyether containing two 2,6-disubstituted 1,3,5,7-cis-tetraoxadecalin systems was obtained under thermodynamic conditions from a dynamic combinatorial virtual library with templating cesium ions (> 95 % yield, see schematic representation) relative to kinetic syntheses (< 8 % yields in their macropolycyclization steps), even when the same template was used.