Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma

被引：35

作者：

Ayyad, Seif-Eldin N. ^{[1
]}

Makki, Mohamed S. ^{[1
]}

Al-kayal, Nazeeha S. ^{[1
]}

Basaif, Salim A. ^{[1
]}

El-Foty, Kalid O. ^{[1
]}

Asiri, Abdullah M. ^{[1
]}

Alarif, Walied M. ^{[2
]}

Badria, Farid A. ^{[3
]}

机构：

[1] King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah 21589, Saudi Arabia

[2] King Abdulaziz Univ, Fac Marine Sci, Marine Chem Dept, Jeddah 21589, Saudi Arabia

[3] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 01期

关键词：

Brown algae; Dictyota dichotoma; Diterpenoids; DNA damage; Cytotoxicity; Antioxidant; DICTYOTA; METABOLITES;

D O I：

10.1016/j.ejmech.2010.10.033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new diterpenes Amijiol acetate (3), dolabellane, Dolabellatrienol (4), and dolastane, 10-diacetate (9) were isolated together with the previously described Pachydictyol A (1), Isopachydictyol A (2), 8 beta-hydroxypachydictyol A (5), Amijiol (6), Isodictyohemiacetal (7) and Dictyol C (8) from the Red Sea brown alga Dictyota dichotoma var. implexa. The structures and relative stereochemistry of the new diterpenoids were proposed on the basis of their spectral data. Compounds 3 and 9 have potent activity against DNA damage, cytotoxicity against WI-38, HepG2, and MCF-7 cell lines, and antioxidant using ABTS and erythrocytes hemolysis. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：175 / 182

页数：8

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