Specific inhibition of hepatitis C viral gene expression by non-polar (phenylalkyl)phosphonates

被引：2

作者：

Amberg, S

Tamke, A

Caselmann, WH

Engels, JW

机构：

[1] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60439 Frankfurt, Germany

[2] Univ Bonn, Dept Med 1, D-5300 Bonn, Germany

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期

关键词：

D O I：

10.1081/NCN-120023086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Different phenylalkyl backbone modified antisense oligonucleotides complementary to the Hepatitis C virus (HCV) RNA nucleotides 326-342 were synthesized. The lipohilic character of modified oligonucleotides was determined from RP-HPLC retention times. The inhibitory effect of these antisense oligonucleotides on HCV gene expression was analyzed in an in vitro test system.

引用

页码：1631 / 1634

页数：4