Clinical Significance of Urinary Liver-Type Fatty Acid-Binding Protein in Diabetic Nephropathy of Type 2 Diabetic Patients

被引:149
作者
Kamijo-Ikemori, Atsuko [1 ,2 ]
Sugaya, Takeshi [1 ]
Yasuda, Takashi [1 ]
Kawata, Takehiro [3 ]
Ota, Akio [3 ]
Tatsunami, Shinobu [4 ]
Kaise, Ruriko [5 ]
Ishimitsu, Toshihiko [6 ]
Tanaka, Yasushi [3 ]
Kimura, Kenjiro [1 ]
机构
[1] St Marianna Univ, Sch Med, Dept Hypertens & Nephrol, Kanagawa, Japan
[2] St Marianna Univ, Sch Med, Dept Anat, Kanagawa, Japan
[3] St Marianna Univ, Sch Med, Dept Endocrinol & Metab, Kanagawa, Japan
[4] St Marianna Univ, Sch Med, Fac Med Educ & Culture, Med Stat Unit, Kanagawa, Japan
[5] Senpo Tokyo Takanawa Hosp, Ctr Hlth, Tokyo, Japan
[6] Dokyo Univ, Sch Med, Dept Hypertens & Cardiorenal Med, Mibu, Tochigi, Japan
关键词
PROGRESSION; DISEASE; INJURY;
D O I
10.2337/dc10-1392
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE-Urinary liver-type fatty acid binding protein (L-FABP) is a promising indicator of tubular but not glomerular damage. The aim of this study was to evaluate the clinical usefulness of urinary L-FABP as a prognostic biomarker in impaired diabetic nephropathy in type 2 diabetes. RESEARCH DESIGN AND METHODS-This investigation involved a cross-sectional and longitudinal analysis of the relationship between urinary L-FABP levels and progressive nephropathy. Urinary L-FABP was measured with enzyme-linked immunosorbent assay. In the cross-sectional analysis, the association of urinary L-FABP, with the severity of diabetic nephropathy, was investigated in 140 patients with type 2 diabetes and in 412 healthy control subjects. Of the patients in the former study, 104 have been followed for 4 years. The progression of diabetic nephropathy was defined as progressive albuminuria, end-stage renal disease, or induction of hemodialysis. RESULTS-Urinary L-FABP levels were progressively increased in subjects with normo-, micro-, or macroalbuminuria and further increased in patients with end-stage renal disease. In the longitudinal analysis, high urinary L-FABP levels were associated with the increase in albuminuria, progression to end-stage renal disease, or induction of hemodialysis. This was particularly demonstrated in the subgroup of patients without renal dysfunction (n = 59), where high urinary L-FABP levels were associated with the progression of diabetic nephropathy. CONCLUSIONS-Urinary L-FABP accurately reflected the severity of diabetic nephropathy in type 2 diabetes, and its level was high in the patients with normoalbuminuria. Moreover, higher urinary L-FABP was a risk factor for progression of diabetic nephropathy.
引用
收藏
页码:691 / 696
页数:6
相关论文
共 9 条
[1]   Urinary fatty acid-binding protein as a new clinical marker of the progression of chronic renal disease [J].
Kamijo, A ;
Kimura, K ;
Sugaya, T ;
Yamanouchi, M ;
Hikawa, A ;
Hirano, N ;
Hirata, Y ;
Goto, A ;
Omata, M .
JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2004, 143 (01) :23-30
[2]   Revised Equations for Estimated GFR From Serum Creatinine in Japan [J].
Matsuo, Seiichi ;
Imai, Enyu ;
Horio, Masaru ;
Yasuda, Yoshinari ;
Tomita, Kimio ;
Nitta, Kosaku ;
Yamagata, Kunihiro ;
Tomino, Yasuhiko ;
Yokoyama, Hitoshi ;
Hishida, Akira .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2009, 53 (06) :982-992
[3]   Chronic hypoxia and tubulointerstitial injury: A final common pathway to end-stage renal failure [J].
Nangaku, Masaomi .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (01) :17-25
[4]   Urinary Liver-Type Fatty Acid-Binding Protein Predicts Progression to Nephropathy in Type 1 Diabetic Patients [J].
Nielsen, Stine Elkjaer ;
Sugaya, Takeshi ;
Hovind, Peter ;
Baba, Tsuneharu ;
Parving, Hans-Henrik ;
Rossing, Peter .
DIABETES CARE, 2010, 33 (06) :1320-1324
[5]   Mechanisms of Disease: the hypoxic tubular hypothesis of diabetic nephropathy [J].
Singh, Dhruv K. ;
Winocour, Peter ;
Farrington, Ken .
NATURE CLINICAL PRACTICE NEPHROLOGY, 2008, 4 (04) :216-226
[6]   THE METABOLIC SIGNIFICANCE OF MAMMALIAN FATTY-ACID-BINDING PROTEINS - ABUNDANT PROTEINS IN SEARCH OF A FUNCTION [J].
SWEETSER, DA ;
HEUCKEROTH, RO ;
GORDON, JI .
ANNUAL REVIEW OF NUTRITION, 1987, 7 :337-359
[7]   STRUCTURAL AND FUNCTIONAL-ASPECTS OF CYTOSOLIC FATTY-ACID-BINDING PROTEINS [J].
VEERKAMP, JH ;
VANKUPPEVELT, THMSM ;
MAATMAN, RGHJ ;
PRINSEN, CFM .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1993, 49 (06) :887-906
[8]   STRUCTURAL AND FUNCTIONAL FEATURES OF DIFFERENT TYPES OF CYTOPLASMIC FATTY ACID-BINDING PROTEINS [J].
VEERKAMP, JH ;
PEETERS, RA ;
MAATMAN, RGHJ .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1081 (01) :1-24
[9]   Renal L-type fatty acid-binding protein in acute ischemic injury [J].
Yamamoto, Tokunori ;
Noiri, Eisei ;
Ono, Yoshinari ;
Doi, Kent ;
Negishi, Kousuke ;
Kamijo, Atsuko ;
Kimura, Kenjiro ;
Fujita, Toshiro ;
Kinukawa, Tsuneo ;
Taniguchi, Hideki ;
Nakamura, Kazuo ;
Goto, Momokazu ;
Shinozaki, Naoshi ;
Ohshima, Shinichi ;
Sugaya, Takeshi .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2007, 18 (11) :2894-2902