Vibrio cholerae Triggers SOS and Mutagenesis in Response to a Wide Range of Antibiotics: a Route towards Multiresistance

被引：168

作者：

Baharoglu, Zeynep ^{[1
,2
]}

Mazel, Didier ^{[1
,2
]}

机构：

[1] Inst Pasteur, Dept Genomes & Genet, Unite Plasticite Genome Bacterien, F-75015 Paris, France

[2] CNRS, URA2171, F-75015 Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 05期

关键词：

ESCHERICHIA-COLI; STAPHYLOCOCCUS-AUREUS; GENE-EXPRESSION; INDUCTION; INHIBITION; RESISTANCE; INTEGRON; CELLS;

D O I：

10.1128/AAC.01549-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibiotic resistance development has been linked to the bacterial SOS stress response. In Escherichia coli, fluoroquinolones are known to induce SOS, whereas other antibiotics, such as aminoglycosides, tetracycline, and chloramphenicol, do not. Here we address whether various antibiotics induce SOS in Vibrio cholerae. Reporter green fluorescent protein (GFP) fusions were used to measure the response of SOS-regulated promoters to subinhibitory concentrations of antibiotics. We show that unlike the situation with E. coli, all these antibiotics induce SOS in V. cholerae.

引用

页码：2438 / 2441

页数：4

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