Severe neurotoxicity, ototoxicity and nephrotoxicity following high-dose cisplatin and amifostine

被引:188
作者
Sastry, J
Kellie, SJ
机构
[1] Childrens Hosp, Oncol Unit, Westmead, NSW, Australia
[2] Univ Sydney, Discipline Paediat & Child Hlth, Sydney, NSW 2006, Australia
关键词
amifostine; cisplatin; nephrotoxicity; neurotoxicity;
D O I
10.1080/08880010590964381
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cisplatin in higher doses have been used routinely in the treatment of childhood tumours including neuroblastoma and germ cell tumors. Amifostine, a broad-spectrum cytoprotector of normal tissues, has been approved by U.S. Food and Drug Administration for use in patients receiving cisplatin. Such administration of amifostine has been reported to reduce cisplatin-related toxicities in some studies, but not all. The authors report a case of severe toxicity with cisplatin in a girl with epithelial cell carcinoma of the ovary despite the use of amifostine.
引用
收藏
页码:441 / 445
页数:5
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