Protein tyrosine kinases Src and Csk: a tail's tale

被引：79

作者：

Cole, PA ^{[1
]}

Shen, K ^{[1
]}

Qiao, YF ^{[1
]}

Wang, DX ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2003年 / 7卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.cbpa.2003.08.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Csk and Src are two protein tyrosine kinases with similar amino acid sequences but very different structures and functions. Csk catalyzes a tail phosphorylation reaction on Src and thereby restrains Src's activity and oncogenic potential. Comparative analysis of the domain interactions in these enzymes provides a lesson in signalling diversity and mechanisms of enzyme regulation. The molecular basis of the specificity of Csk targeting the Sire tail appears to involve both local and long-range interactions and illustrates the complexity of selective targeting in post-translational modification.

引用

页码：580 / 585

页数：6

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