The attenuation of dysfunctional emotional processing with stimulant medication: An fMRI study of adolescents with ADHD

被引:91
作者
Posner, Jonathan [1 ,2 ]
Maia, Tiago V. [1 ,2 ]
Fair, Damien [4 ]
Peterson, Bradley S. [1 ,2 ]
Sonuga-Barke, Edmund J. S. [5 ]
Nagel, Bonnie J. [3 ,4 ]
机构
[1] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA
[2] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
[3] Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97201 USA
[4] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA
[5] Univ Southampton, Sch Psychol, Southampton, Hants, England
关键词
Stroop; Medial prefrontal cortex; Cognitive control; Emotional lability; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; MEDIAL PREFRONTAL CORTEX; COUNTING STROOP; CHILDREN; INTERFERENCE; RELIABILITY; DOPAMINE; MODEL; ORGANIZATION;
D O I
10.1016/j.pscychresns.2011.02.005
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Functional neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have focused on the neural correlates of cognitive control. However, for many youths with ADHD, emotional lability is an important clinical feature of the disorder. We aimed to identify the neural substrates associated with emotional lability that were distinct from impairments in cognitive control and to assess the effects that stimulants have on those substrates. We used functional magnetic resonance imaging (fMRI) to assess neural activity in adolescents with (N=15) and without (N= 15) ADHD while they performed cognitive and emotional versions of the Stroop task that engage cognitive control and emotional processing, respectively. The participants with ADHD were scanned both on and off stimulant medication in a counterbalanced fashion. Controlling for differences in cognitive control, we found that during the emotional Stroop task, adolescents with ADHD as compared with controls demonstrated atypical activity in the medial prefrontal cortex (mPFC). Stimulants attenuated activity in the mPFC to levels comparable with controls. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:151 / 160
页数:10
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