Metabolic Syndrome and Risks of Colon and Rectal Cancer: The European Prospective Investigation into Cancer and Nutrition Study

被引：108

作者：

Aleksandrova, Krasimira ^{[1
]}

Boeing, Heiner ^{[1
]}

Jenab, Mazda ^{[2
]}

Bueno-de-Mesquita, H. Bas ^{[3
,5
]}

Jansen, Eugene ^{[5
]}

van Duijnhoven, Franzel J. B. ^{[4
,5
]}

Fedirko, Veronika ^{[2
]}

Rinaldi, Sabina ^{[2
]}

Romieu, Isabelle ^{[2
]}

Riboli, Elio ^{[6
]}

Romaguera, Dora ^{[6
]}

Overvad, Kim ^{[8
]}

Ostergaard, Jane Nautrup ^{[8
]}

Olsen, Anja ^{[9
]}

Tjonneland, Anne ^{[9
]}

Boutron-Ruault, Marie-Christine ^{[10
,11
]}

Clavel-Chapelon, Francoise ^{[10
,11
]}

Morois, Sophie ^{[10
,11
]}

Masala, Giovanna ^{[12
]}

Agnoli, Claudia ^{[13
]}

Panico, Salvatore ^{[14
]}

Tumino, Rosario ^{[15
,16
]}

Vineis, Paolo ^{[7
]}

Kaaks, Rudolf ^{[17
]}

Lukanova, Annekatrin ^{[17
]}

Trichopoulou, Antonia ^{[18
,19
]}

Naska, Androniki ^{[18
]}

Bamia, Christina ^{[18
]}

Peeters, Petra H. ^{[4
]}

Rodriguez, Laudina ^{[20
]}

Buckland, Genevieve ^{[21
]}

Sanchez, Maria-Jose ^{[22
,23
]}

Dorronsoro, Miren ^{[24
,25
]}

Huerta, Jose-Maria ^{[26
]}

Barricarte, Aurelio ^{[27
]}

Hallmans, Goran ^{[28
]}

Palmqvist, Richard ^{[29
]}

Khaw, Kay-Tee ^{[30
]}

Wareham, Nicholas ^{[31
]}

Allen, Naomi E. ^{[32
]}

Tsilidis, Konstantinos K. ^{[32
]}

Pischon, Tobias ^{[1
,33
]}

机构：

[1] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, D-14558 Nuthetal, Germany

[2] Int Agcy Res Canc, F-69372 Lyon, France

[3] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[4] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[5] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[6] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England

[7] Univ London Imperial Coll Sci Technol & Med, MRC HPA Ctr Environm & Hlth, Sch Publ Hlth, London, England

[8] Aarhus Univ, Dept Epidemiol, Inst Publ Hlth, Aarhus, Denmark

[9] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[10] Inst Gustave Roussy, INSERM, Ctr Res Epidemiol & Populat Hlth, U1018, F-94805 Villejuif, France

[11] Paris S Univ, UMRS 1018, F-94805 Villejuif, France

[12] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[13] Fdn IRCCS, Nutr Epidemiol Unit, Ist Nazl Tumori, Milan, Italy

[14] Univ Naples Federico II, Dept Clin & Expt Med, Fac Med & Surg, Naples, Italy

[15] MP Arezzo Hosp, Canc Registry, Ragusa, Italy

[16] MP Arezzo Hosp, Histopathol Unit, Ragusa, Italy

[17] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[18] Univ Athens, WHO Collaborating Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, Sch Med, GR-10679 Athens, Greece

[19] Hellen Hlth Fdn, Athens, Greece

[20] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[21] Catalan Inst Oncol ICO IDIBELL, Unit Nutr Environm & Canc, Canc Epidemiol Res Programme, Barcelona, Spain

[22] Andalusian Sch Publ Hlth, Granada, Spain

[23] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Granada, Spain

[24] Basque Govt, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[25] CIBERESP, San Sebastian, Spain

[26] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[27] Consortium Biomed Res, Navarre Publ Hlth Inst, Murcia, Spain

[28] Umea Univ, Div Nutr Res, Dept Publ Hlth & Clin Med, Umea, Sweden

[29] Umea Univ, Unit Pathol, Dept Med Biosci, Fac Med, Umea, Sweden

[30] Univ Cambridge, Unit Clin Gerontol, Dept Publ Hlth & Primary Care, Sch Clin Med, Cambridge CB2 1TN, England

[31] Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England

[32] Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Clin Med, Div Med Sci, Oxford, England

[33] Max Delbruck Ctr Mol Med MDC, Mol Epidemiol Grp, Berlin, Germany

来源：

CANCER PREVENTION RESEARCH | 2011年 / 4卷 / 11期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

COLORECTAL-CANCER; INSULIN-RESISTANCE; DIAGNOSIS;

D O I：

10.1158/1940-6207.CAPR-11-0218

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metabolic syndrome (MetS) is purportedly related to risk of developing colorectal cancer; however, the association of MetS, as defined according to recent international criteria, and colorectal cancer has not been yet evaluated. In particular, it remains unclear to what extent the MetS components individually account for such an association. We addressed these issues in a nested case-control study that included 1,093 incident cases matched (1: 1) to controls by using incidence density sampling. Conditional logistic regression was used to estimate relative risks (RR) and 95% CIs. MetS was defined according to the criteria of the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATPIII), the International Diabetes Federation (IDF), and the 2009 harmonized definition. Among individual components, abdominal obesity (RR = 1.51; 95% CI: 1.16-1.96) was associated with colon cancer, whereas abnormal glucose metabolism was associated with both colon (RR = 2.05; 95% CI: 1.57-2.68) and rectal cancer (RR = 2.07; 95% CI: 1.45-2.96). MetS, as defined by each of the definitions, was similarly associated with colon cancer (e. g., RR = 1.91; 95% CI: 1.47-2.42 for MetS by NCEP/ATPIII), whereas MetS by NCEP/ATPIII, but not IDF or harmonized definition, was associated with rectal cancer (RR = 1.45; 95% CI: 1.02-2.06). Overall, these associations were stronger in women than in men. However, the association between MetS and colorectal cancer was accounted for by abdominal obesity and abnormal glucose metabolism such that MetS did not provide risk information beyond these components (likelihood ratio test P = 0.10 for MetS by NCEP/ATPIII). These data suggest that simple assessment of abnormal glucose metabolism and/or abdominal obesity to identify individuals at colorectal cancer risk may have higher clinical utility than applying more complex MetS definitions. Cancer Prev Res; 4(11); 1873-83. (C) 2011 AACR.

引用

页码：1873 / 1883

页数：11

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