Glycogen synthase kinase-3: Properties, functions, and regulation

被引：378

作者：

Ali, A ^{[1
]}

Hoeflich, KP ^{[1
]}

Woodgett, JR ^{[1
]}

机构：

[1] Ontario Canc Inst, Div Expt Therapeut, Toronto, ON M5G 2M9, Canada

来源：

CHEMICAL REVIEWS | 2001年 / 101卷 / 08期

关键词：

D O I：

10.1021/cr000110o

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

A study on glycogen synthase kinase (GSK)-3 was presented. The isolation, characterization and regulation of GSK-3 activity was discussed. The role of GSK-3 in the Wnt signaling pathway was studied. The inhibition of GSK-3 by GBP/FRAT, GSK-3 phosphorylation of β-catenin and APC and regulation of GSK-3 by other signaling pathways was also described.

引用

页码：2527 / 2540

页数：14

共 175 条

[1]

Mechanism of activation of protein kinase B by insulin and IGF-1 [J].

Alessi, DR ;

Andjelkovic, M ;

Caudwell, B ;

Cron, P ;

Morrice, N ;

Cohen, P ;

Hemmings, BA .

EMBO JOURNAL, 1996, 15 (23) :6541-6551

[2]

REDUCED BRAIN INOSITOL IN LITHIUM-TREATED RATS [J].

ALLISON, JH ;

STEWART, MA .

NATURE-NEW BIOLOGY, 1971, 233 (43) :267-&

[3]

Animal-vegetal axis patterning mechanisms in the early sea urchin embryo [J].

Angerer, LM ;

Angerer, RC .

DEVELOPMENTAL BIOLOGY, 2000, 218 (01) :1-12

[4]

INVITRO AND INVIVO INHIBITION OF INOSITOL MONOPHOSPHATASE BY THE BISPHOSPHONATE L-690,330 [J].

ATACK, JR ;

COOK, SM ;

WATT, AP ;

FLETCHER, SR ;

RAGAN, CI .

JOURNAL OF NEUROCHEMISTRY, 1993, 60 (02) :652-658

[5]

Control of apoptosis by Rel/NF-κB transcription factors [J].

Barkett, M ;

Gilmore, TD .

ONCOGENE, 1999, 18 (49) :6910-6924

[6]

Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3 [J].

Beals, CR ;

Sheridan, CM ;

Turck, CW ;

Gardner, P ;

Crabtree, GR .

SCIENCE, 1997, 275 (5308) :1930-1933

[7]

EMBRYONIC LETHALITY AND LIVER DEGENERATION IN MICE LACKING THE RELA COMPONENT OF NF-KAPPA-B [J].

BEG, AA ;

SHA, WC ;

BRONSON, RT ;

GHOSH, S ;

BALTIMORE, D .

NATURE, 1995, 376 (6536) :167-170

[8]

An essential role for NF-kappa B in preventing TNF-alpha-induced cell death [J].

Beg, AA ;

Baltimore, D .

SCIENCE, 1996, 274 (5288) :782-784

[9]

Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β [J].

Behrens, J ;

Jerchow, BA ;

Würtele, M ;

Grimm, J ;

Asbrand, C ;

Wirtz, R ;

Kühl, M ;

Wedlich, D ;

Birchmeier, W .

SCIENCE, 1998, 280 (5363) :596-599

[10]

ATP CITRATE-LYASE AND GLYCOGEN-SYNTHASE KINASE-3-BETA IN 3T3-L1 CELLS DURING DIFFERENTIATION INTO ADIPOCYTES [J].

BENJAMIN, WB ;

PENTYALA, SN ;

WOODGETT, JR ;

HOD, Y ;

MARSHAK, D .

BIOCHEMICAL JOURNAL, 1994, 300 :477-482

← 1 2 3 4 5 6 7 8 9 10 →