Breast cancer resistance protein (BCRP/ABCG2)

被引：171

作者：

Staud, F ^{[1
]}

Pavek, P ^{[1
]}

机构：

[1] Charles Univ, Dept Pharmacol & Toxicol, Fac Pharm, Hradec Kralove 50005, Czech Republic

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2005年 / 37卷 / 04期

关键词：

efflux transporter; multidrug resistance; stem cell; pharmacokinetics;

D O I：

10.1016/j.biocel.2004.11.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer resistance protein (BCRP) was identified 7 years ago as the most recent member of ABC drug efflux membrane transporters. It is a 655 amino acid peptide with an ability to extrude a wide variety of chemical compounds from the cells. Today, it is considered as one of three major transporters causing drug resistance in mammalian cells. It is also distributed in epithelia involved in drug disposition with major role in the placenta, liver and intestine. In addition, BCRP is responsible for the "side population" phenotype of stem cells and seems to play a significant role in protection against hypoxia. BCRP inhibitors are currently searched for to overcome drug resistance and to improve the pharmacokinetics, mainly intestinal absorption, of substrate drugs. Mutant BCRP has also been used as a selectable marker in stem cell gene therapy applications. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：720 / 725

页数：6

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