Polymorphic analysis of the matrix metalloproteinase-9 gene and susceptibility to sporadic abdominal aortic aneurysm

被引：12

作者：

Armani, Chiara ^{[1
]}

Curcio, Michele ^{[1
]}

Barsotti, Maria Chiara ^{[1
]}

Santoni, Tatiana ^{[1
]}

Di Stefano, Rossella ^{[1
]}

Dell'Omodarme, Matteo ^{[1
]}

Brandi, Maria Luisa ^{[1
]}

Ferrari, Mauro ^{[1
]}

Scatena, Fabrizio ^{[1
]}

Carpi, Angelo ^{[1
]}

Balbarini, Alberto ^{[1
]}

机构：

[1] Univ Pisa, Cardiac & Thorac Dept, I-56124 Pisa, Italy

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2007年 / 61卷 / 05期

关键词：

metalloproteinases; aneurysm; polymorphism;

D O I：

10.1016/j.biopha.2006.12.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Abdominal aortic aneurysm (AAA) has a multifactorial aetiology and the importance of genetic components is getting increasing interest. Alteration in the structure of the vascular extracellular matrix has been described in AAA. Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins which alter the vessel wall stability. We evaluated two different polymorphisms, a CA repeat and a cytosine to thymidine transition in the promoter sequence of MMP-9 gene for frequency in 146 patients with AAA. We compared the results with those of 156 healthy subjects. No difference was found in the allelic distribution of either polymorphisms. We therefore found no evidence that MMP-9 is a marker of susceptibility for AAA. (c) 2006 Elsevier Masson SAS. All rights reserved.

引用

页码：268 / 271

页数：4

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